The town of Klissura lies at a distance of 30 km west of Karlovo. It has a population of 1 600 inhabitants. The settlement is located at the western part of the Karlovo Valley at an altitude of 720 m. The region specializes in growing oil-bearing cultures.

In the region of Klissura there are remains of prehistoric settlements, Thracian mounds, ruins of an ancient and a medieval fortresses. The cave "Mechata dupka"/The bear's den/ has been populated during the Neolith. Klissura is mentioned in the Ottoman registry books from 1576 under the name of Parasadim Derbend and has had a well-developed stock breeding and rose oil trade at that time. After the failure of the April Rebellion from 1876 the settlement is burned down. Klissura is the home town of the publisher Hristo Danov and the writer Iliya Blaskov.

The tourist sights of the town are: the History Museum, the church "Uspenie Bogorodichno"/The Assumption/ (1885) and restored Revival period houses.